Week 12 odds start Thanksgiving Day with the Bears-Lions, Redskins-Cowboys, Falcons-Saints. With Alex Smith out for the year, the Washington Redskins are 7.5-point underdogs to the Pokes. The horrific Jacksonville Jaguars are laying four-points on the road at Buffalo, in a game in which bettors will take a close look at weather reports to see if the Florida-based team will have freezing temperatures just below Lake Ontario. OffshoreInsiders.comwill have the winning picks. 
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| Thursday, Nov 22, 2018 – NFL Football Game | |||||
| 12:30 PM | 105 | Chicago Bears | -3 | -115 | 44½ |
| 106 | Detroit Lions | 3 | -105 | 44½ | |
| 04:30 PM | 107 | Washington Redskins | +7½ | -105 | 39½ |
| 108 | Dallas Cowboys | -7½ | -115 | 39½ | |
| 08:20 PM | 109 | Atlanta Falcons | 12 | -110 | 60½ |
| 110 | New Orleans Saints | -12 | -110 | 60½ | |
| Sunday, Nov 25, 2018 – NFL Football Game | |||||
| 01:00 PM | 251 | Jacksonville Jaguars | -4 | 100 | 37 |
| 252 | Buffalo Bills | 4 | -120 | 37 | |
| 01:00 PM | 253 | Oakland Raiders | +10½ | -110 | 42½ |
| 254 | Baltimore Ravens | -10½ | -110 | 42½ | |
| 01:00 PM | 255 | San Francisco 49ers | 3 | 105 | 52½ |
| 256 | Tampa Bay Buccaneers | -3 | -125 | 52½ | |
| 01:00 PM | 257 | New York Giants | 6 | -110 | 45½ |
| 258 | Philadelphia Eagles | -6 | -110 | 45½ | |
| 01:00 PM | 261 | New England Patriots | -8½ | -110 | 46 |
| 262 | New York Jets | +8½ | -110 | 46 | |
| 01:00 PM | 263 | Seattle Seahawks | 3 | 105 | 45 |
| 264 | Carolina Panthers | -3 | -125 | 45 | |
| 04:25 PM | 265 | Miami Dolphins | 8 | -110 | 51½ |
| 266 | Indianapolis Colts | -8 | -110 | 51½ | |
| 04:25 PM | 269 | Pittsburgh Steelers | -4 | 100 | 47½ |
| 270 | Denver Broncos | 4 | -120 | 47½ | |
| 08:20 PM | 271 | Green Bay Packers | 5 | -108 | 48½ |
| 272 | Minnesota Vikings | -5 | -112 | 48½ | |
| Monday, Nov 26, 2018 – NFL Football Game | |||||
| 08:15 PM | 273 | Tennessee Titans | 6 | -115 | 41½ |
| 274 | Houston Texans | -6 | -105 | 41½ | |