The Bills defeated Minnesota 27-6 in Week 3. They essentially covered a 37.5-point spread, which is akin to the 40.5-point spread the No. 16 UMBC covered against No. 1 Virginia during last year’s NCAA Tournament (won by 20 and were 20.5-point underdogs).

Biggest Upsets in NFL History:

New York Jets (+18) over Baltimore Colts (16-7, Super Bowl III)

Baltimore Colts (+18) over New England Patriots (33-27, 9/18/78)

Buffalo Bills (+16.5) over Minnesota Vikings (27-6, 9/23/18)

Since 2003, teams that were 16.5-point underdogs or higher were 0-23.

—–

The 49ers had 30-1 (+3000) odds to win Super Bowl LIII going into Week 3. If Jimmy Garoppolo’s knee injury sidelines him for the season, San Francisco’s odds will jump to 70-1 (+7000), according to BetDSI oddsmakers. The Niners were 8-1 to win the NFC West going into Week 3.

Garoppolo is worth 5-6 points to the spread, depending on the opponent.