Week 2 opening NFL odds released by Betonline is the home of the opening line. These odds were made public before the Sunday and Monday Night Football games, hence of course, not all lines are yet posted. It starts Thursday night with a divisional matchup between Baltimore and Cincinnati. OffshoreInsiders.com will have all the winners.
| 08:20 PM | 101 | Baltimore Ravens | -1½ | -110 | o | 44 |
| 102 | Cincinnati Bengals | +1½ | -110 | o | 44 | |
| Sunday, Sep 16, 2018 – NFL Football Game | ||||||
| 01:00 PM | 261 | Indianapolis Colts | 5 | -110 | o | 47½ |
| 262 | Washington Redskins | -5 | -110 | o | 47½ | |
| 01:00 PM | 263 | Carolina Panthers | +4½ | -103 | o | 44 |
| 264 | Atlanta Falcons | -4½ | -117 | o | 44 | |
| 01:00 PM | 267 | Los Angeles Chargers | -7½ | -104 | o | 44 |
| 268 | Buffalo Bills | +7½ | -116 | o | 44 | |
| 01:00 PM | 271 | Kansas City Chiefs | 5 | -115 | o | 49½ |
| 272 | Pittsburgh Steelers | -5 | -105 | o | 49½ | |
| 01:00 PM | 273 | Miami Dolphins | -1½ | -110 | o | |
| 274 | New York Jets | +1½ | -110 | o | ||
| 01:00 PM | 275 | Philadelphia Eagles | -3 | -120 | o | |
| 276 | Tampa Bay Buccaneers | 3 | 100 | o | ||
| 01:00 PM | 277 | Cleveland Browns | 8 | -110 | o | 50 |
| 278 | New Orleans Saints | -8 | -110 | o | 50 | |
| 04:05 PM | 279 | Arizona Cardinals | 10 | -110 | o | |
| 280 | Los Angeles Rams | -10 | -110 | o | ||
| 04:05 PM | 281 | Detroit Lions | 3 | -105 | o | |
| 282 | San Francisco 49ers | -3 | -115 | o | ||
| 04:25 PM | 283 | New England Patriots | -1½ | -110 | o | |
| 284 | Jacksonville Jaguars | +1½ | -110 | o | ||
| 04:25 PM | 285 | Oakland Raiders | +4½ | -105 | o | |
| 286 | Denver Broncos | -4½ | -115 | o | ||
| 08:20 PM | 287 | New York Giants | 3 | -110 | o | 44½ |
| 288 | Dallas Cowboys | -3 | -110 | o | 44½ | |